HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Burke, A. M. Articles by Reivich, M. Search for Related Content PubMed PubMed Citation Articles by Burke, A. M. Articles by Reivich, M.

Regional variation in cerebral perfusion during acute hypertension

Cerebrovascular Research Center, Department of Neurology, University of Pennsylvania, Philadelphia, PA.

Regional cerebral blood flow (rCBF) was measured in rats to define the autoregulatory response at different levels of hypertension. Mean arterial blood pressure (MABP) was raised with IV metaraminol. rCBF was measured using ¹⁴C-iodoantipyrine. Autoregulation was intact in normotensive animals and those with MABP of 152 to 158 mm Hg. At higher pressures, autoregulation was abnormal and heterogeneous. Hyperperfusion was most prominent in cerebellum, parietal gray matter, thalamus, striatum, and pons. These anatomic sites are recognized sites of hypertensive hemorrhage in humans.

Address correspondence and reprint requests to Dr. Burke, Department of Neurology, Michael Reese Hospital and Medical Center, 29th and Ellis Avenue, Chicago, IL 60616.

Supported by USPHS Program Project Grant NS 10939–11.

Received January 6, 1984. Accepted for publication April 24, 1986.

This article has been cited by other articles:

				B. K. Dandapani, S. Suzuki, R. E. Kelley, Y. Reyes-Iglesias, and R. C. Duncan Relation Between Blood Pressure and Outcome in Intracerebral Hemorrhage Stroke, January 1, 1995; 26(1): 21 - 24. [Abstract] [Full Text]