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Hyperactive vestibulo-ocular reflex in cerebellar degeneration

Pathogenesis and treatment

Ocular Motor Neurophysiology Laboratory and the Neurology Service of the Cleveland Veterans Administration Medical Center: the Departent of Neurology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH.

We studied a patient with a cerebellar degeneration and hyperactive vestibulo-ocular reflex (VOR). He complained of oscillopsia and blurred vision with head movement. A twofold increase in VOR gain (peak eye velocity/peak head velocity) at high frequencies was associated with a VOR time constant of 6 seconds (low normal). Visual cancellation ("suppression") of the VOR and smooth pursuit were also abnormal. We hypothesized that his high VOR gain was due to dysfunction of olivocerebellar projections. Physostigmine reduced his VOR gain, consistent with the hypothesis that these projections are cholinergic.

Address correspondence and reprint requests to Dr. Leigh. Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University. 2074 Ahington Road. Cleveland, OH 44106.

Supported in part by the Veterans Administration, the Evenor Armington Fund, and NASA contract 9–17439.

Received February 14, 1986. Accepted for publication April 24, 1986.

This article has been cited by other articles:

				M. F. Walker and D. S. Zee Cerebellar Disease Alters the Axis of the High-Acceleration Vestibuloocular Reflex J Neurophysiol, November 1, 2005; 94(5): 3417 - 3429. [Abstract] [Full Text] [PDF]