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cerebral Vascular Disease Research Center and the Departments of Neurology and Anatomy and Cell Biology, University of Miami School of Medicine, Miami, FL.
To investigate the relationships of local cerebral glucose utilization (ICMRgl) and blood flow (ICBF) during physiologic activation, awake Wistar rats received unilateral stimulation of the large facial whiskers (vibrissae) and were studied by carbon-14 double-label autoradiography. Activation was followed by increased ICMRgl and lCBF in appropriate forebrain structures. There was an overall preservation of metabolism/blood flow coupling during periods of somatosensory activation despite small but significant increases (14 to 22%) in the coupling ratio of the barrel field. Prolonged activation may give rise to an intracortical redistribution of ICBF within the barrel field.
Address correspondence and reprint requests to Dr. Ginsberg. Department of Neurology (D4-5). University of Miami School of Medicine, PO Box 016960, Miami, FL.
Supported by USPHS Grants NS-05820-20 and NS-22603-01 and by Grant-in-Aid 85-1258 of the American Heart Association, with funds contributed in part by the Greater Miami Chapter. Dr. Ginsberg is the recipient of a Jacob Javits Neuroscience Investigator Award. Dr. Dietrich is an Established Investigator of the American Heart Association.
Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.
Received February 6, 1986. Accepted for publication April 10, 1986.
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