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Glutamate and malate dehydrogenase activities in Joseph disease and olivopontocerebellar atrophy

Department of Neurology, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, TX.

The activities of brain glutamate dehydrogenase and malate dehydrogenase were not statistically different in samples from patients with autosomal dominant olivopontocerebellar atrophy or Joseph disease compared with control subject samples. These two enzymes are thus not involved in the pathogenesis of these two separate dominantly inherited diseases.

Address correspondence and reprint requests to Dr. Rosenberg, Department of Neurology, UTHSCD, 5323 Harry Hines Blvd., Dallas, TX 75235.

Received October 31, 1985. Accepted for publication April 10, 1986.

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