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Structural proteins of the opaque muscle fibers in Duchenne muscular dystrophy

From The First Department of Internal Medicine, Kumamoto University Medical School, Kumamoto, Japan.

We studied the structural proteins of the "opaque fibers" (OFs) in muscle biopsies from 12 patients, aged 4 to 24 years, with Duchenne muscular dystrophy. The electrophoretic patterns of myofibrillar proteins indicated three groups of opaque fibers: the first (OF a) had an almost normal electrophoretogram, the second (OF b₁) showed a clear decrease of 55,000 dalton protein (desmin), and the third (OF b₂) exhibited a great reduction in -actinin and desmin. The data suggest that some OFs are pathologic fibers in the degenerative process of Duchenne dystrophy.

Address correspondence and reprint requests to Dr. Uchino, The First Department of Internal Medicine, Kumamoto University Medical School, 1–1–1 Honjo Kumamoto 860 Japan.

Accepted for publication December 14, 1984.