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NEUROLOGY 1985;35:1335
© 1985 American Academy of Neurology

Cerebral organization of affect suggested by temporal lobe seizures

T. A. Hurwitz, MBChB, MRCP(UK), FRCP(C), J. A. Wada, MD, B. D. Kosaka, BA and E. H. Strauss, PhD

From the Department of Psychiatry (Dr. Hurwitz). Neuropsychiatric Unit, Vancouver, BC; Divisions of Neurological Sciences and Neurology (Drs. Wada and Kosaka), Health Sciences Center Hospital, University of British Columbia; and the Department of Psychology (Dr. Strauss), University of Victoria, Canada.

A right-handed woman with independent left- and right-sided temporal lobe discharges was studied by continuous EEG and videotape monitoring for 3 weeks. Changes in affect were noted in the immediate and extended postictal periods and varied with the side of discharge. After a left-sided discharge, she became globally aphasic and depressed. Right-sided discharges evoked laughing and postictal hypomania. These manifestations were attributed to contralateral hemispheric disinhibition after ipsilateral seizure inactivation. This case provides evidence that the speech-dominant hemisphere subserves positive feelings and the nondominant hemisphere negative ones.

Address correspondence and reprint requests to Dr. Hurwitz, Department of Psychiatry, Neuropsychiatric Unit, East 1 Clinic, UBC-HSCH, 2255 Wesbrook Mall. Vancouver, BC V6T 2A1. Canada.

Supported in part by Medical Research Council of Canada grants.

Accepted for publication December 6, 1984




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