HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Oksanen, V. Articles by Grönhagen-Riska, C. Search for Related Content PubMed PubMed Citation Articles by Oksanen, V. Articles by Grönhagen-Riska, C.

Angiotensin converting enzyme in cerebrospinal fluid

A new assay

Department of Neurology, IVth Department of Medicine, Helsinki University Central Hospital, and Minerva Institulp for Medical Research, Helsinki, Finland.

Serum and CSF angiotensin converting enzyme (ACE) were measured by a new inhibitor binding assay in 32 patients with sarcoidosis, 49 with neurologic diseases, and 38 controls. In neurosarcoidosis, 11 of 20 patients had high levels of CSF ACE. In systemic sarcoidosis without neurologic abnormality, only 1 of 12 patients had elevated CSF ACE. The highest value was observed in a patient with widespread meningeal sarcoidosis. High values were also observed in patients with bacterial meningitis or malignant tumors of the CNS. Fluctuation in successive analyses correlated to clinical course of neurosarcoidosis. CSF ACE analysis seems useful in diagnosis and follow-up of neurosarcoidosis.

Address correspondence and reprint requests to Dr. Oksanen. Minerva Institute, PO Box 819, SF-00101 Helsinki 10, Finland.

This study was supported by grants from Finnish Cultural Foundation (Subdivision of Hame), Tampere Antituberculous Foundation, the Finnish Academy, and Sigrid Jusélius Foundation.

Accepted for publication November 14, 1984

This article has been cited by other articles:

				S. Pawate, H. Moses, and S. Sriram Presentations and outcomes of neurosarcoidosis: a study of 54 cases QJM, July 1, 2009; 102(7): 449 - 460. [Abstract] [Full Text] [PDF]

				F G Joseph and N J Scolding Neurosarcoidosis: a study of 30 new cases J. Neurol. Neurosurg. Psychiatry, March 1, 2009; 80(3): 297 - 304. [Abstract] [Full Text] [PDF]

				F G Joseph and N J Scolding Sarcoidosis of the nervous system Practical Neurology, August 1, 2007; 7(4): 234 - 244. [Abstract] [Full Text] [PDF]

				N. Porter, H.L. Beynon, and H.S. Randeva Endocrine and reproductive manifestations of sarcoidosis QJM, August 1, 2003; 96(8): 553 - 561. [Full Text] [PDF]

				J. A. Erickson, R. Cousin, J. T. Wu, and E. R. Ashwood Quantitative Spectrophotometric Microplate Assay for Angiotensin-converting Enzyme in Cerebrospinal Fluid Clin. Chem., June 1, 2003; 49(6): 970 - 972. [Full Text] [PDF]

				J.P. Zajicek, N.J. Scolding, O. Foster, M. Rovaris, J. Evanson, I.F. Moseley, J.W. Scadding, E.J. Thompson, V. Chamoun, D.H. Miller, et al. Central nervous system sarcoidosis—diagnosis and management QJM, February 1, 1999; 92(2): 103 - 117. [Abstract] [Full Text] [PDF]

				Grand Rounds--Hammersmith Hospital: Meningeal granulomas: sarcoidosis or tuberculosis? BMJ, February 25, 1995; 310(6978): 517 - 520. [Full Text]

				D. M. Peeples, B. J. Stern, V. Jiji, and K. S. Sahni Germ Cell Tumors Masquerading as Central Nervous System Sarcoidosis Arch Neurol, May 1, 1991; 48(5): 554 - 556. [Abstract] [PDF]

				I. Rubinstein and V. Hoffstein Angiotensin-Converting Enzyme in Neurosarcoidosis Arch Neurol, March 1, 1987; 44(3): 249 - 250. [Abstract] [PDF]