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Treatment of progressive supranuclear palsy with tricyclic antidepressants

Neurology Service, Veterans Administration Medical Center, North-port, NY: and the Departments of Neurology and Neurobiology and Behavior, State University of New York at Stony Brook, NY.

After a single patient with progressive supranuclear palsy (PSP) improved when given amitriptyline, we compared the effects of amitriptyline, desipramine, and placebo on the symptoms and signs of four patients with PSP in a double-blind, double-crossover manner. There was good correlation between the use of tricyclic agents and symptomatic improvement, although all patients remained disabled. Amitriptyline produced better overall improvement, whereas desipramine preferentially improved apraxia of eyelid opening.

Address correspondence and reprint requests to Dr. Newman, Department of Neurology, HSC T12-020, SUNY at Stony Brook, Stony Brook, NY 11794.

Accepted for publication December 5, 1984.

This article has been cited by other articles:

				K. Kompoliti, C. G. Goetz, I. Litvan, K. Jellinger, and M. Verny Pharmacological Therapy in Progressive Supranuclear Palsy Arch Neurol, August 1, 1998; 55(8): 1099 - 1102. [Abstract] [Full Text] [PDF]

				J. Ghika and J. Bogousslavsky Presymptomatic Hypertension Is a Major Feature in the Diagnosis of Progressive Supranuclear Palsy Arch Neurol, September 1, 1997; 54(9): 1104 - 1108. [Abstract] [PDF]