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NEUROLOGY 1985;35:1140
© 1985 American Academy of Neurology

Peripheral neuropathy in hypereosinophilic syndrome

Alison Wichman, MD, Fritz Buchthal, MD, Gholam H. Pezeshkpour, MD and Anthony S. Fauci, MD

National Institutes of Health. NINCDS (Drs. Buchthal and Wichman). NIAID (Dr. Fauci)., Hethesda, MD: and the Armed Forces Institute of Pathology (Dr. Pezeshkpourl, Washington, DC.

We evaluated seven patients with the hypereosinophilic syndrome (HES) to define the clinicopathologic spectrum of the peripheral neuropathy. Clinically, three had evident polyneuropathy; the others were asymptomatic, although they had electrophysiologic evidence of neuropathy. Nerve conduction studies and EMG were compatible with axonal neuropathy. Morphometry of sural nerves from four patients ranged from normal to marked axonal loss, more prominent in large myelinated fibers. Demyelination was rare, and there was no evidence of vasculitis. Neuropathy may be produced by an eosinophil-derived neurotoxin.

Address correspondence and reprint requests to Dr. Wichman, NIH. Building 10, Room 5N226. Bethesda, MD 20205.

This paper was presented in part at the thirty-sixth annual meeting of the American Academy of Neurology, Boston, MA. April 1984.

Accepted for publication November 30, 1984.




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