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NEUROLOGY 1985;35:1063
© 1985 American Academy of Neurology

Levamisole is ineffective in the treatment of amyotrophic lateral sclerosis

Marcelo R. Olarte, MD and Stephen Q. Shafer, MD, MPH

Neurological Institute, New York, NY.

Fifty-nine patients with amyotrophic lateral sclerosis participated in a 12-month, double-blind crossover trial. The patients were given either levamisole 150 mg or placebo in identical tablets once a week orally, and a rating of neurologic signs and symptoms was recorded on monthly visits. The patients were crossed over at 6 months. Levamisole had no effect on the rate of score decline in the 20 patients who completed the trial.

Address correspondence and reprint requests to Dr. Olarte, Neurological Institute, 710 West 168th Street, New York, NY 10032.

Supported by a grant from the Muscular Dystrophy Association and NIMH Clinical Research Center Grant MH 30906-05.

Accepted for publication October 18, 1984.






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