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CSF ß-endorphin and ß-lipotropin in Alzheimer's disease and multi-infarct dementia

Department of Neurology, and Department I of Obstetrics and Gynecology, University of Helsinki, Finland.

We measured CSF levels of the opioid peptides ß-endorphin and ß-lipotropin in patients with Alzheimer's disease, multi-infarct dementia and controls. In both dementia moups, the mean concentration of ß-endomhin was significantly lower than in controls. The mean ß-lipotropin levels did not differ significantly in the two groups. The low CSF ß-endorphin level may relate generally to dementia.

Address correspondence and reprint requests to Dr. Sulkava, Department of Neurology. University of Helsinki, 00290 Helsinki, Finland.

Supported hy grants from the Research Council for Medicine of the Academy of Finland, the Orion Research Foundation, the Sigrid Juselius Foundation, and the Paula Foundation, Dr. Erkinjuntti is the recipient of a grant from the University Central Hospital, Helsinki.

Accepted for publication November 7, 1984.

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