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Plasmalogen analysis in erythrocyte membranes of adrenoleukodystrophy

Department of Neurology (Drs. Antoku, Sakai. and Iwashita), National Chikugo Hospital, Chikugo City, Japan; and the Department of Neurology (Drs. Goto and Kuroiwa), Neurological Institute, Faculty of Medicine, Kyushu IJniversity, Fukuoka, Japan.

Very long-chain fatty acids accumulate in both adrenoleukodystrophy and Zellweger's syndrome. Plasmalogen content is decreased in Zellweger's syndrome. We therefore analyzed plasmalogen in erythrocyte membrane glycerophospholipids of three patients with adrenoleukodystrophy and eight normal controls. There was no significant difference in the ratio of plasmalogen and diacyl forms in the phosphatidylethanolamine class of the patients and controls. This observation suggests that plasmalogen metabolism differs in adrenoleukodystrophy and Zellweger's syndrome.

Address correspondence and reprint requests to Dr. Antoku, Department of Neurology, National Chikugo Hospital, 515 Kurakazu, Chikugo City, 833 Japan.

Accepted for publication November 1, 1984.