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NEUROLOGY 1985;35:1003
© 1985 American Academy of Neurology

Alteration of thrornboxane and prostacyclin levels in experimental spinal cord injury

C. Y. Hsu, MD, PhD, P. V. Halushka, MD, PhD, E. L. Hogan, MD, N. L. Banik, PhD, W. A. Lee, BS and P. L. Perot, Jr, MD, PhD

Department of Neurology, Medical University of South Carolina, Charleston, SC.

We measured levels of thromboxane B2 and 6-keto-PGF10 in rabbit spinal cord and cat CSF after impact injury to spinal cord. Rabbit tiissue thromboxane B2 levels increased more than 6-keto-PGF10. In cat, CSF thromboxane B, was higher the first hour postinjury; CSF 6-keto-PGF10 also increased, but less so. These results imply activation of arachidonic acid metabolism. The relatively greater increase of thromboxane B, suggests that thromboxane-prostacyclin imbalance may contribute to post-traumatic ischemia.

Address correspondence and reprint requests to Dr. Hsu, Department of Neurology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425.

Supported by Grants NS 11066, CM 27673, and HL 29566 from US Public Health Service and South Carolina State Appropriation for Research. Dr. Hsu is a recipient of NINCDS Teacher Investigator Devdopment Award NS 00792.

Presented in part at the thirty-fourth and thirty-fifth annual meetings of the American Academy of Neurology, San Diego. CA, April 1983, and Boston, MA, April 1984.

Accepted for publication November 1, 1984.




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