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NEUROLOGY 1985;35:928
© 1985 American Academy of Neurology

Freeze-fracture analysis of the muscle fiber plasma membrane in Duchenne dystrophy

Dionisio Peluchetti, MD, Marina Mora, PhD, Alessandra Protti, MD and Ferdinando Cornelio, MD

Neuromuscular Research Service, "C. Besta" Neurological Institute and The Center for the Study of Peripheral Neuropathies and Neuromuscular Diseases, University of Milan, Milan, Italy.

The intramembrane particle density in freeze-fractured muscle fiber plasma membranes did not differ in 4 patients with Duchenne dystrophy and 4 normal subjects. However, we confirmed reported loss of orthogonal arrays and increased density of caveolae in dystrophic muscle.

Address correspondence and reprint requests to Dr. Peluchetti, Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy.

Supported in part by a grant from the "Dino Ferrari Foundation" and by CNR grant No. 82 0137 04.

Accepted for publication September 27, 1984






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