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NEUROLOGY 1985;35:921
© 1985 American Academy of Neurology

Cyanide-induced parkinsonism

A clinicopathologic report

Ryan J. Uitti, A. H. Rajput, E. M. Ashenhurst and B. Rozdilsky

Department of Clinical Neurological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

An 18-year-old man ingested 975 to 1,300 mg of potassium cyanide in a suicide attempt. He was treated and survived the poisoning episode, but then had severe parkinsonian syndrome, characterized primarily by akinesia and rigidity. He died 19 months after the drug overdose. At autopsy, major destructive changes were found in the globus pallidus and putamen, whereas the melanin-containing zone of substantia nigra was intact. This is the first clinicopathologic report of parkinsonism as a result of cyanide poisoning.

Address correspondence and reprint requests to Dr. Rajput, Department of Clinical Neurological Sciences, University Hospital, Saskatoon, Saskatchewan S7N OXO, Canada.

Accepted for publication October 14, 1984.




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