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NEUROLOGY 1985;35:918
© 1985 American Academy of Neurology

Pergolide mesylate

Lack of cardiac toxicity in patients with cardiac disease

Caroline M. Tanner, MD, Ramesh Chhablani, MD, Christopher G. Goetz, MD and Harold L. Klawans, MD

Departments of Neurological Sciences (Drs. Tanner, Goetz, and Klawans) and Medicine (Dr. Chhablani), Rush-Preshyterian-St. Luke's Medical Center, Chicago, IL.

In a 12-month open-label trial, pergolide mesylate was administered in doses with antiparkinsonian efficacy to six patients with stable heart disease. Cardiac status did not worsen in any patient. Parkinson's disease improved in all patients. Pergolide is a safe and effective therapy for Parkinson's disease, even in patients with heart disease.

Address correspondence and reprint requests to Dr. Tanner, Rush-Preshyterian-St. Luke's Medical Center, Neurological Sciences, 1753 West Congress Parkway, Chicago, IL 60612.

Supported in part by grants from the United Parkinson Foundation, Boothroyd Foundation, Chicago, IL, and Eli Lilly Company, Indianapolis, IN. Dr. Goetz is the recipient of an NINCDS Teacher-Investigator Award

Presented in part at the thirty-fourth annual meeting of the American Academy of Neurology, Washington, DC, April 1982.

Accepted for publication October 3, 1984.







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