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Substance P, enkephalins, somatostatin, cholecystokinin, oxytocin, and vasopressin in human spinal cord

Departments of Neurology and Clinical Neurophysiology (Dr. Schoenen) and Neuropathology (Dr. Reznik). University of Liège, Bavière Hospital, Liège; and Neuropathology (Drs. Lotstra. Vierendeels, and Vanderhaeghen). Neuropeptide Research Laboratory, Erasme Hospital, Free University of Brussels, Queen Elisabeth Medical Foundation, Brussels, Belgium.

Several neuropeptides were immunohistologically studied in normal human spinal cords. Substance P, methionine-enkephalin, leucine-enkephalin, and cholecystokinin positive fibers were found in all cytoarchitectonic layers, with a specific distribution pattern for each peptide. Somatostatin, oxytocin, and vasopressin immunoreactivities were restricted to particular spinal layers. Perikarya and proximal dendrites were visualized and classified by comparison with previous Golgi analyses. Substance P was contained in "radiate cells" of layer III, methionine-enkephalin in marginal neurons as well as in layer II "stellate cells," and somatostatin in layer II "islet cells." Several results differed from those reported in other species. Chemical neuroanatomy may provide new insights into the neuronal organization of the human spinal cord.

Address correspondence and reprint requests to Dr. Schoenen, Department of Neurology and Clinical Neurophysiology, University of Liège, Bavière Hospital. 66 Bd. de la Constitution, B-4020 Liège, Belgium.

J. Schoenen is a Research Associate of the National Fund for Scientific Research (Belgium)

Accepted for publication October 17, 1984

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