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NEUROLOGY 1985;35:866
© 1985 American Academy of Neurology

Histoanatomic observations of the brain in early infantile autism

Margaret Bauman, MD and Thomas L. Kemper, MD

Children's Neurology Service (Dr. Bauman), Massachusetts General Hospital; and the Neurology and Neuropathology Services (Dr. Kemper). Boston City Hospital, Boston, MA.

Early infantile autism is a behaviorally defined syndrome that is often associated with abnormalities on neurologic examination and seizures. We report on the brain of a 29-year-old autistic man as compared with that of an age- and sex-matched normal control, using gapless sections of whole brain. Abnormalities were found in the hippocampus, subiculum, entorhinal cortex, septal nuclei, mamillary body, selected nuclei of the amygdala, neocerebellar cortex, roof nuclei of the cerebellum, and inferior olivary nucleus.

Address correspondence and reprint requests to Dr. Bauman, Department of Neurology, Boston City Hospital, 818 Harrison Avenue, Boston, MA 02118.

Supported in part by a gift from Dr. Norman Geschwind, Department of Neurology, Beth Israel Hospital, Boston, MA.

Presented in part at the thirty-sixth annual meeting of the American Academy of Neurology, Boston, MA, April 1984.

Accepted for publication October 14, 1984.




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