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NEUROLOGY 1985;35:818
© 1985 American Academy of Neurology

New observations in reducing body myopathy

Stirling Carpenter, MD, George Karpati, MD and Paul Holland, PhD

Departments of Neurology-Neurosurgery and Pathology, McGill University, and the Montreal Neurological Institute.

Numerous autofluorescent reducing bodies were found in deltoid and biceps muscle biopsies of a 7-year-old girl with progressive, asymmetric muscle weakness. The structures were composed of tubular filaments as seen by electronmicroscopy. They seemed to have formed around nuclei. An excess of two unidentified proteins was found in muscle homogenates. This patient, like one previously reported, had high serum titers of antibodies to coxsackievirus, but her serum, when tested by indirect immunocytochemistry, did not react with the reducing bodies.

Address correspondence and reprint requests to Dr. Carpenter, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4.

This work was supported by grants from the Muscular Dystrophy Association of Canada and the Medical Research Council of Canada.

Accepted for publication September 27, 1984.




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