Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Grimaldi, L. M.E.
Right arrow Articles by Arnason, B. G.W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grimaldi, L. M.E.
Right arrow Articles by Arnason, B. G.W.
NEUROLOGY 1985;35:813
© 1985 American Academy of Neurology

Oligoclonal IgA bands in multiple sclerosis and subacute sclerosing panencephalitis

Luigi M.E. Grimaldi, MD, Raymond P. Roos, MD, Eric A. Nalefski and Barry G.W. Arnason, MD

Department of Neurology and the Brain Research Institute, University of Chicago, Chicago, IL.

CSF oligoclonal IgG bands are often found in MS or cerebral diseases in which there is chronic antigenic stimulation. Using agarose isoelectric focusing followed by immunoblotting, we found oligoclonal IgA bands in CSF from 16 of 20 randomly selected patients with MS, 7 of 7 with subacute sclerosing panencephalitis (SSPE), and 0 of 10 with noninflammatory neurologic or psychiatric disease. IgA bands did not correlate with the course or stage of MS. Serial samples from two patients with MS and one with SSPE demonstrated only minor changes in IgA banding pattern. One MS patient without oligoclonal IgG bands had oligoclonal IgA bands, indicating that the latter test may be helpful in the diagnosis of MS.

Address correspondence and reprint requests to Dr. Ross, Department of Neurology, University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637.

Supported by grants from The National Multiple Sclerosis Society (MSRG1512-A-1) and from the Kroc Foundation.

Accepted for publication September 27, 1984.




This article has been cited by other articles:


Home page
 Arch NeurolHome page
R. B. Tenser, K. A. Hay, and J. A. Aberg
Immunoglobulin G Immunosuppression of Multiple Sclerosis: Suppression of All Three Major Lymphocyte Subsets
Arch Neurol, April 1, 1993; 50(4): 417 - 420.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by AAN Enterprises, Inc.