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Department of Neurology (Drs. Petroff and Prichard) and the Department of Molecular Biophysics and Biochemistry, JW Gibbs Laboratory (Mr. Behar and Drs. Alger, den Hollander, and Shulman). Yale University, New Haven, CT.
We determined cerebral intracellular pH in living rabbits and rats under physiologic conditions, using phosphorus NMR spectroscopy and new titration curves thought to be appropriate for brain. Mean values for the two species were, respectively, 7.14 ± 0.04 (SD) and 7.13 ± 0.03. These are toward the alkaline end of the range of values obtained by other methods, as values reported by other NMR workers also tend to be.
Address correspondence and reprint requests to Dr. Prichard, Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510.
Supported by grants from the United States Public Health Service (GM 30287 and AM 27121) and the Esther A. and Joseph Klingenstein Foundation. Accepted for publication September 27, 1984.
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