Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Heilig, C. W.
Right arrow Articles by Frey, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Heilig, C. W.
Right arrow Articles by Frey, W., II
NEUROLOGY 1985;35:762
© 1985 American Academy of Neurology

Dementia without Alzheimer pathology

Charles W. Heilig, MD, David S. Knopman, MD, Angeline R. Mastri, MD and William Frey, II, PhD

Departments of Laboratory Medicine and Pathology, Neurology and Psychiatry, University of Minnesota Hospitals, and the Psychiatry Research Laboratories of St. Paul Ramsey Medical Center.

We studied five demented patients who, on neuropathologic examination, had cell loss and Lewy bodies in substantia nigra and locus ceruleus and few Alzheimer-type changes. The nucleus basalis had minimal cell loss in three patients and was not available in two. The lesions in the substantia nigra and locus ceruleus were unlikely to account for the dementia, and other structural or biochemical derangements, probably cortical but possibly subcortical, must also have been present but not visible at the light microscopic level.

Address correspondence and reprint requests to Dr. Knopman, Department of Neurology, Box 295 Mayo, University of Minnesota Hospitals, Minneapolis, MN 55455.

An earlier version of this work was the winner of the G. Milton Shy Award of the American Academy of Neurology for 1984 (Dr. Heilig).

Supported by NIH grant NS14583 and by Grant No. 8347 from the St. Paul Ramsey Hospital Medical Education and Research Foundation.

Accepted for publication September 5, 1984.




This article has been cited by other articles:


Home page
 NeurologyHome page
J. E. Galvin, J. Pollack, and J. C. Morris
Clinical phenotype of Parkinson disease dementia.
Neurology, November 14, 2006; 67(9): 1605 - 1611.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
D. G. Lichter, A. J. Corbett, G. M. Fitzgibbon, O. R. Davidson, J. K. A. Hope, G. V. Goddard, K. J. Sharpies, and M. Pollock
Cognitive and Motor Dysfunction in Parkinson's Disease: Clinical, Performance, and Computed Tomographic Correlations
Arch Neurol, August 1, 1988; 45(8): 854 - 860.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
R. M. Torack and J. C. Morris
The Association of Ventral Tegmental Area Histopathology With Adult Dementia
Arch Neurol, May 1, 1988; 45(5): 497 - 501.
[Abstract] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
J. L. Cummings
Intellectual Impairment in Parkinson's Disease: Clinical, Pathologic, and Biochemical Correlates
J Geriatr Psychiatry Neurol, January 1, 1988; 1(1): 24 - 36.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
H. C. Chui, J. A. Mortimer, U. Slager, C. Zarow, W. Bondareff, and D. D. Webster
Pathologic Correlates of Dementia in Parkinson's Disease
Arch Neurol, October 1, 1986; 43(10): 991 - 995.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by AAN Enterprises, Inc.