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NEUROLOGY 1985;35:758
© 1985 American Academy of Neurology

Activity, creatine kinase, and myoglobin in Duchenne muscular dystrophy

A clue to etiology?

Julaine M. Florence, MHS, RPT, Peter T. Fox, MD, G. James Planer, BA and Michael H. Brooke, MD

Jerry Lewis Neuromuscular Research Center, Department of Neurology, Washington University Medical School, St. Louis, MO.

Large and seemingly random fluctuations in the serum levels of creatine kinase (CK) and myoglobin (Mb) have been noted in patients with Duchenne muscular dystrophy. We studied seven affected boys, aged 2 to 9 years. Blood was drawn for CK and Mb every 4 hours, and the boys' activity was documented hourly for 4 days. There was a close correlation between serum levels of CK and Mb with physical activity. Fluctuations in serum levels of CK and Mb are not random and may result from an abnormality of fatty acid metabolism.

Address correspondence and reprint requests to Dr. Florence, Box 8111, Washington University Medical Center, 660 S. Euclid, St. Louis, MO 63110.

Supported by a Center Grant from the Muscular Dystrophy Association and by Public Health Service Research Grant No. RR-36 from the General Clinical Research Center Branch, Division of Research Facilities and Resources, Bethesda, MD.

Presented at the thirty-sixth annual meeting of the American Academy of Neurology, Boston, MA, April 1984.

Accepted for publication September 21, 1984.




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