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Departments of Neurology (Drs. Bendheim and Berg) and Pediatrics (Dr. Berg), and the Division of Clinical Pharmacy (Dr. Reale), University of California, San Francisco, CA.
In a patient with hyperkalemic periodic paralysis, metaproterenol prevented muscular weakness and hyperkalemia in periods of rest after exercise. During a severe attack, the drug rapidly corrected hyperkalemia and seemed to enhance the return of strength. The action of metaproterenol may involve a ß-adrenergic-mediated increase of potassium transport via the sodium-potassium pump.
Address correspondence and reprint requests to Dr. Bendheim, Department of Pathological Neurobiology, Institute for Basic Research, 1050 Forest Hill Rd., Staten Island, NY 10314.
Accepted for publication September 12, 1984.
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