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NEUROLOGY 1985;35:746
© 1985 American Academy of Neurology

ß-Adrenergic treatment of hyperkalemic periodic paralysis

Paul E. Bendheim, Elaine Obstarczyk Reale and Bruce O. Berg

Departments of Neurology (Drs. Bendheim and Berg) and Pediatrics (Dr. Berg), and the Division of Clinical Pharmacy (Dr. Reale), University of California, San Francisco, CA.

In a patient with hyperkalemic periodic paralysis, metaproterenol prevented muscular weakness and hyperkalemia in periods of rest after exercise. During a severe attack, the drug rapidly corrected hyperkalemia and seemed to enhance the return of strength. The action of metaproterenol may involve a ß-adrenergic-mediated increase of potassium transport via the sodium-potassium pump.

Address correspondence and reprint requests to Dr. Bendheim, Department of Pathological Neurobiology, Institute for Basic Research, 1050 Forest Hill Rd., Staten Island, NY 10314.

Accepted for publication September 12, 1984.




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J. Neurol. Neurosurg. PsychiatryHome page
M G Hanna, J Stewart, A H V Schapira, N W Wood, J A Morgan-Hughes, and N M F Murray
Salbutamol treatment in a patient with hyperkalaemic periodic paralysis due to a mutation in the skeletal muscle sodium channel gene (SCN4A)
J. Neurol. Neurosurg. Psychiatry, August 1, 1998; 65(2): 248 - 250.
[Abstract] [Full Text]




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