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Newly treated childhood epilepsy

A prospective study of recurrences and side effects

Department of Pediatrirs, Dalhousie University, and I.W. Killam Hospital for Children, Halifax, Nova Scotia.

Eighty-two newly diagnosed children were started on anticonvulsant therapy and followed prospectively for 12 to 36 months. Compliance was excellent. However, 41% had a recurrent seizure within 6 months of starting therapy despite "adequate" serum levels. Recurrences were least frequent in those with generalized tonic-clonic seizures or those with a single seizure plus epileptiform EEG before treatment. Toxicity screening led to unnecessary drug change in two children. Seven other children had behavioral side effects requiring drug change.

Address correspondence and reprint requests to Dr. Camfield, I.W. Killam Hospital for Children, PO Box 3070, Halifax, NS B3J 3G9, Canada.

Supported in part by a grant from Abhott Laboratories Canada Ltd.

Presented in part at the Child Neurology Society Meeting, Williamsburg, VA, 1983.

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