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Peripheral neuropathy, high serum IgM, and paraproteinemia in mother and son

Department of Neurology (Drs. Busis, Sagar, Schiff, and Lagigian) and the Hematology-Oncology Unit (Dr. Kwiatkowski), Massachusetts General Hospital, Boston; the Department of Neurology (Dr. Halperin), State University of New York at Stony Brook, NY; and the Department of Neurology (Dr. Stefansson), University of Chicago, IL.

A mother and son had peripheral neuropathy, abnormal elevation of serum IgM, and paraproteinemia. These patients may have a familial disorder of immune regulation with antibody-mediated neuropathy or a familial neuropathy with a secondary immune response.

Address correspondence and reprint requests to Dr. Busis, Clinical Neurophysiology Laboratory, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114.

Presented in part at the thirty-sixth annual meeting of the American Academy of Neurology, Boston, MA, April 1984.

Accepted for publication September 12, 1984.

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