NEUROLOGY 1985;35:453
© 1985 American Academy of Neurology
Heterogeneity in dementia of the Alzheimer type
Evidence of subgroups
Richard Mayeux, MD,
Yaakov Stern, PhD and
Susan Spanton
Department of Neurology, Columbia University, College of Physicians and Surgeons, and the Presbyterian Hospital in the City of New York
We reviewed records of 121 consecutive patients with dementia of the Alzheimer type. Patients with myoclonus or extrapyramidal signs had greater intellectual decline and functional impairment in daily activities. Among patients studied over 4 years, there were four groups: benign—little to no progression; myoclonic—severe intellectual decline and frequent mutism after younger onset; extrapyramidal—severe intellectual and functional decline and frequent psychotic symptoms; typical—a gradual progression of intellectual and functional decline, but without other distinguishing features. Except for the group with myoclonus, no subgroup was segregated by age at onset or other demographic variables. This study suggests that dementia of the Alzheimer type is heterogeneous, and that certain clinical manifestations may be useful in predicting outcome.
Address correspondence and reprint requests to Dr. Mayeux, 710 West 168th Street, Neurological Institute. New York. NY 10032.
Supported in part by the Charles S. Robertson Memorial Gift for Alzheimer's Disease from the Banbury Fund and a federal grant (AG 02802) to Dr. Mayeux. Data were stored and analyzed on a CLINFO system (NIH RK00645).
Presented in part at the thirty-sixth annual meeting of the American Academy of Neuroloky, Boston. MA, April 1984.
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J. C. Morris, M. Drazner, K. Fulling, E. A. Grant, and J. Goldring
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D. P. Dastoor and M. G. Cole
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American Journal of Alzheimer's Disease and Other Dementias,
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R. P. Friedland, E. Koss, J. V. Haxby, C. L. Grady, J. Luxenberg, M. B. Schapiro, and J. Kaye
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Ann Intern Med,
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J. Botwinick, M. Storandt, L. Berg, and S. Boland
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May 1, 1988;
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J. R. Atack, M. F. Beal, C. May, J. A. Kaye, M. F. Mazurek, A. D. Kay, and S. I. Rapoport
Cerebrospinal Fluid Somatostatin and Neuropeptide Y: Concentrations in Aging and in Dementia of the Alzheimer Type With and Without Extrapyramidal Signs
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March 1, 1988;
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E. LaBarge, L. S. Rosenman, K. Leavitt, and T. Cristiani
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Neurorehabil Neural Repair,
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R. J. KIERNAN, J. MUELLER, J. W. LANGSTON, and C. VAN DYKE
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F. J. Huff, F. Boller, F. Lucchelli, R. Querriera, J. Beyer, and S. Belle
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W. Bondareff, C. Q. Mountjoy, M. Roth, M. N. Rossor, L. L. Iversen, and G. P. Reynolds
Age and Histopathologic Heterogeneity in Alzheimer's Disease: Evidence for Subtypes
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L. Volicer, B. Seltzer, Y. Rheaume, K. Fabiszewski, L. Herz, R. Shapiro, and P. Innis
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Journal of Applied Gerontology,
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J. Botwinick, M. Storandt, and L. Berg
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J. Leverenz and S. M. Sumi
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M. Schweber
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