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Periodic leg movements in sleep

Effect of clonazepam treatment

Faculty of Medicine, Technion-Israel Institute of Technology (Dr. Ohanna); Department of Neurology, Rothschild Medical Center (Dr. Peled); Department of Internal Medicine A, Rambam University Hospital (Dr. Rubin); and Sleep Lab, Faculty of Medicine, Technion-IsraeI Institute of Technology (Mr. Zomer and Prof. Lavie), Haifa, Israel.

Periodic leg movements in sleep were diagnosed in 8 patients with insomnia and in 12 patients with hypersomnia. Polysom-nography did not reveal any difference in the number of leg movements in these groups, the mean duration of a leg movement, or the number of activity epochs. Those with insomnia, however, had a shorter intermovement interval than those with hypersomnia, with more leg movements in each activity epoch. Treatment with 0.5 to 2 mg clonazepam improved subjective complaints and decreased the number of leg movements without affecting the intermovement interval or movement duration.

Address correspondence and reprint requests to Prof. Lavie, Sleep Lab, Faculty of Medicine, Technion, Haifa 32000, Israel.

Accepted for publication July 17, 1984.

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