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NEUROLOGY 1985;35:397
© 1985 American Academy of Neurology

Brainstem gliomas of childhood

Magnetic resonance imaging

Roger J. Packer, MD, Robert A. Zimmerman, MD, Thomas G. Luerssen, MD, Leslie N. Sutton, MD, Larissa T. Bilaniuk, MD, Derek A. Bruce, MD and Luis Schut, MD

Divisions of Neurology (Dr. Packer) and Neurosurgery (Drs. Luerssen, Sutton, Bruce, and Schut), The Children's Hospital of Philadelphia, and the Departments of Neurology (Dr. Packer), Pediatrics (Dr. Packer), Neuroradiology (Drs. Zimmerman and Bilaniukj, and Neurosurgery (Drs. Sutton, Bruce, and Schut), University of Pennsylvania, Philadelphia.

We compared magnetic resonance imaging (MRI) and CT on 16 children with brainstem gliomas. MRI demonstrated masses of decreased signal intensity, which enlarged and distorted brainstems in all patients with active disease and showed brainstem abnormalities in 21 of 23 studies (91%). In one-half of the patients, MRI showed more extensive disease than did CT. Exophytic portions of tumors were shown well on MRI. MRI was more sensitive than CT in demonstrating disease relapse.

Address correspondence and reprint requests to Dr. Packer, Division of Neurology, The Children's Hospital of Philadelphia, One Children's Center, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104.

Supported in part by the Eagles Fly for Leukemia Fund and NCI Grant No. CA 14489. Dr. Packer is the recipient of the Junior Faculty Clinical Fellowship of the American Cancer Society.

Accepted for publication July 18, 1984.




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