| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Neurobehavior Unit, West Los Angeles VAMC (Brentwood Division) and Neurobehavior Training Program, Department of Neurology (Drs. Cummings, Benson, and Read), UCLA School of Medicine; the Department of Research and Development (Dr. Hill), West Los Angeles VAMC (Brentwood Division); and the Section of Neuropsychogeriatries, Department of Psychiatry and Behavioral Sciences (Dr. Read), UCLA School of Medicine, Los Angeles, CA.
Speech and language assessment in 30 patients with dementia of the Alzheimer type and in 70 normal controls revealed that all Alzheimer patients were aphasic. Throughout most of the course, the language disorder resembled transcortical sensory aphasia, and increasing language impairment correlated with increasing severity of dementia. Aphasia was present regardless of age of onset or family history of dementia. Aphasia is an important diagnostic criterion of dementia of the Alzheimer type.
Address correspondence to Dr. Cummings, West Los Angeles VAMC (Brentwood Division), Neurobehavior Unit Ward 256b, 11301 Wilshire Boulevard, Los Angeles, CA 90073.
Supported by the Alzheimer's Disease and Related Disorders Association and by the Veterans Administration. Dr. Read was supported by the Kaiser Foundation and by an NIMH training grant (MH 16590).
Accepted for publication July 17,1984.
This article has been cited by other articles:
|
|
 |
|
  J. Neils-Strunjas, K. Groves-Wright, P. Mashima, and S. Harnish Dysgraphia in Alzheimer's Disease: A Review for Clinical and Research Purposes J Speech Lang Hear Res, December 1, 2006; 49(6): 1313 - 1330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Mendez, D. G. Clark, J. S. Shapira, and J. L. Cummings Speech and language in progressive nonfluent aphasia compared with early Alzheimer's disease Neurology, October 28, 2003; 61(8): 1108 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. O'Hara, J. M. Thompson, H. C. Kraemer, C. Fenn, J. L. Taylor, L. Ross, J. A. Yesavage, A. M. Bailey, and J. R. Tinklenberg Which Alzheimer Patients Are at Risk for Rapid Cognitive Decline? J Geriatr Psychiatry Neurol, January 1, 2002; 15(4): 233 - 238. [Abstract] [PDF]
|
|
|
|
|
|
J. A. Testa, W. W. Beatty, A. C. Gleason, D. M. Orbelo, and E. D. Ross Impaired affective prosody in AD: Relationship to aphasic deficits and emotional behaviors Neurology, October 23, 2001; 57(8): 1474 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. MENDEZ, K. M. PERRYMAN, M. O. PONTÓN, and J. L. CUMMINGS Bilingualism and Dementia J Neuropsychiatry Clin Neurosci, August 1, 1999; 11(3): 411 - 412. [Full Text]
|
|
|
|
 |
|
 J. A. Harasty, G. M. Halliday, J. J. Kril, and C. Code Specific temporoparietal gyral atrophy reflects the pattern of language dissolution in Alzheimer's disease Brain, April 1, 1999; 122(4): 675 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. W. Greene, K. Patterson, J. Xuereb, and J. R. Hodges Alzheimer Disease and Nonfluent Progressive Aphasia Arch Neurol, October 1, 1996; 53(10): 1072 - 1078. [Abstract] [PDF]
|
|
|
|
 |
|
 D. S. Geldmacher and P. J. Whitehouse Evaluation of Dementia N. Engl. J. Med., August 1, 1996; 335(5): 330 - 336. [Full Text] [PDF]
|
|
|
|
|
|
L. A. Klatka, R. B. Schiffer, J. M. Powers, and A. M. Kazee Incorrect Diagnosis of Alzheimer's Disease: A Clinicopathologic Study Arch Neurol, January 1, 1996; 53(1): 35 - 42. [Abstract] [PDF]
|
|
|
|
|
|
L. Bracco, R. Gallato, F. Grigoletto, A. Lippi, V. Lepore, G. Bino, M. P. Lazzaro, F. Carella, T. Piccolo, C. Pozzilli, et al. Factors Affecting Course and Survival in Alzheimer's Disease: A 9-Year Longitudinal Study Arch Neurol, December 1, 1994; 51(12): 1213 - 1219. [Abstract] [PDF]
|
|
|
|
|
|
L. D. McDaniel, T. Lukovits, and K. D. McDaniel Alzheimer's Disease: The Problem of Incorrect Clinical Diagnosis J Geriatr Psychiatry Neurol, October 1, 1993; 6(4): 230 - 234. [Abstract] [PDF]
|
|
|
|
|
|
H. Karbe, A. Kertesz, and M. Polk Profiles of Language Impairment in Primary Progressive Aphasia Arch Neurol, February 1, 1993; 50(2): 193 - 201. [Abstract] [PDF]
|
|
|
|
|
|
E. LaBarge, D. S. Smith, L. Dick, and M. Storandt Agraphia in Dementia of the Alzheimer Type Arch Neurol, November 1, 1992; 49(11): 1151 - 1156. [Abstract] [PDF]
|
|
|
|
|
|
K. D. McDaniel, M. T. Wagner, and B. S. Greenspan The Role of Brain Single Photon Emission Computed Tomography in the Diagnosis of Primary Progressive Aphasia Arch Neurol, December 1, 1991; 48(12): 1257 - 1260. [Abstract] [PDF]
|
|
|
|
|
|
E. P. Feher, R. S. Doody, J. Whitehead, and F. J. Pirozzolo Progressive Nonfluent Aphasia With Dementia: A Case Report J Geriatr Psychiatry Neurol, October 1, 1991; 4(4): 236 - 240. [Abstract] [PDF]
|
|
|
|
|
|
K. A. Bayles Age at Onset of Alzheimer's Disease: Relation to Language Dysfunction Arch Neurol, February 1, 1991; 48(2): 155 - 159. [Abstract] [PDF]
|
|
|
|
|
|
S. Weintraub, N. P. Rubin, and M.-M. Mesulam Primary Progressive Aphasia: Longitudinal Course, Neuropsychological Profile, and Language Features Arch Neurol, December 1, 1990; 47(12): 1329 - 1335. [Abstract] [PDF]
|
|
|
|
|
|
J. Haan, J. B. K. Lanser, I. Zijderveld, I. G. F. van der Does, and R. A. C. Roos Dementia in Hereditary Cerebral Hemorrhage With Amyloidosis-Dutch Type Arch Neurol, September 1, 1990; 47(9): 965 - 967. [Abstract] [PDF]
|
|
|
|
|
|
D. Galasko, M. R. Klauber, C. R. Hofstetter, D. P. Salmon, B. Lasker, and L. J. Thal The Mini-Mental State Examination in the Early Diagnosis of Alzheimer's Disease Arch Neurol, January 1, 1990; 47(1): 49 - 52. [Abstract] [PDF]
|
|
|
|
|
|
M. P. Alexander, B. Hiltbrunner, and R. S. Fischer Distributed Anatomy of Transcortical Sensory Aphasia Arch Neurol, August 1, 1989; 46(8): 885 - 892. [Abstract] [PDF]
|
|
|
|
|
|
H. C. Chui Dementia: A Review Emphasizing Clinicopathologic Correlation and Brain-Behavior Relationships Arch Neurol, July 1, 1989; 46(7): 806 - 814. [Abstract] [PDF]
|
|
|
|
|
|
S. Z. Rapcsak, S. A. Arthur, D. A. Bliklen, and A. B. Rubens Lexical Agraphia in Alzheimer's Disease Arch Neurol, January 1, 1989; 46(1): 65 - 68. [Abstract] [PDF]
|
|
|
|
 |
|
 H. V. Vinters, B. L. Miller, and W. M. Pardridge Brain Amyloid and Alzheimer Disease Ann Intern Med, July 1, 1988; 109(1): 41 - 54. [Abstract] [PDF]
|
|
|
|
 |
|
 R. C. Mohs, J. C. S. Breitner, J. M. Silverman, and K. L. Davis Alzheimer's Disease: Morbid Risk Among First-Degree Relatives Approximates 50% by 90 Years of Age Arch Gen Psychiatry, May 1, 1987; 44(5): 405 - 408. [Abstract] [PDF]
|
|
|
|
|
|
P. N. Tariot and H. Weingartner A Psychobiologic Analysis of Cognitive Failures: Structure and Mechanisms Arch Gen Psychiatry, December 1, 1986; 43(12): 1183 - 1188. [Abstract] [PDF]
|
|
|
|
|
|
C. M. Filley, J. Kelly, and R. K. Heaton Neuropsychologic Features of Early- and Late-Onset Alzheimer's Disease Arch Neurol, June 1, 1986; 43(6): 574 - 576. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
