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NEUROLOGY 1985;35:338
© 1985 American Academy of Neurology

Blind loop syndrome, vitamin E malabsorption, and spinocerebellar degeneration

Mitchell F. Brin, MD, Michael R. Fetell, MD, Peter H.A. Green, MD, Herbert J. Kayden, MD, Arthur P. Hays, MD, Myles M. Behrens, MD and Herman Baker, PhD

Departments of Neurology, Medicine. Neuropathology, and Ophthalmology, Columbia College of Physicians and Surgeons, and New York University School of Medicine, New York, NY; and College of Medicine and Dentistry of New Jersey, Newark. NJ.

A 72 -year-old man had severe malabsorption, progressive retinopathy, and spinocerebellar degeneration 32 years after gastric surgery, blind loop formation, and intestinal bacterial overgrowth. Clinical and pathologic features were typical of vitamin E deficiency; vitamin E was nearly undetectable in serum and profoundly low in adipose tissue. Vitamin E blood levels initially improved on treatment with antibiotics; after additional vitamin E supplementation, there was clinical improvement.

Address correspondence and reprint requests to Dr. Brin, Neurological Institute, 710 West 168th Street, New York, NY 10032.

Supported by a Peggy Engl Fellowship (Dr. Brin), a Muscular Dystrophy Association Center Grant, and NIH # RR00645-12.

Accepted for publication June 29, 1984.






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