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Autoradiographic localization of thyrotropin-releasing hormone (TRH) receptors in human spinal cord

Departments of Biology (Dr. Manaker). Psychiatry (Dr. Winokur), Pharmacology (Drs. Winokur and Rainbow), and Pathology (Dr. Rhodes), University of Pennsylvania. Philadelphia, PA.

Thyrotropin-releasing hormone (TRH) exerts many effects upon spinal cord function in animals, and may also play a role in human spinal cord function. We have used the technique of quantitative autoradiography to anatomically localize specific receptors for TRH within human spinal cord. Highest concentrations of TRH receptors were localized within lamina II, the substantia gelatinosa. A moderate density of TRH receptors was found in lamina IX, the motor neurons of the anterior horn. Low levels of TRH receptors were noted throughout the remainder of the gray matter of the human spinal cord, and no TRH receptors were localized within white matter. This anatomic distribution of TRH receptors within the human spinal cord is consistent with the localization of endogenous TRH and the effects of exogenously applied TRH in animal studies. These results suggest that any effects of TRH on human spinal cord function may be mediated by TRH receptors.

Address correspondence and reprint requests to Dr. Manaker, Department of Pharrnacology/G3, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104.

Portions of this work were completed by the first author in partial fulfillment of the PhD degree from the University of Pennsylvania. The work has been supported by Medical Scientist Training Program NIH 5-T32-GM07170 to S.M., NIMH Research Scientist Development Award MH00044 and NIH NS 18332 lo A.W., 2T32 NS 07064 to C.H.R., and NS 19597, NS 20006, and fellowships from the Alfred P. Sloan Foundation and the Esther A. and Joseph Klingenstein Fund to T.C.R.

Accepted for publication June 19, 1984.

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