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Peripheral blood and CSF T-cell subsets in Japanese MS patients

Department of Internal Medicine, Division of Neurology. Saga Medical School. Saga, Japan.

We analyzed peripheral blood and CSF T-cell subsets in Japanese patients with MS, using an OK series of monoclonal antibodies in an immunofluorescent techniaue. In the Peripheral blood, suppressor. T cells were increased, with a concomitant decrease in helper T cells, after recovery from acute exacerbation, but there was no relationship between T cells in peripheral blood and CSF. In the CSF, acute exacerbation was associated with an increase in Ia-positive cells and a decrease in T cells. CSF pleocytosis (with more than 30% of Ia-positive cells) probably indicated active disease.

Address correspondence and reprint requests to Dr. Kuroda, Department of Internal Medicine, Saga Medical School. Nabeshima. Saga 840-01, Japan.

This work was supported by a grant from The Immunoneurological Disease Research Committee, Ministry of Health and Welfare of Japan.

Accepted for publication June 4, 1984.

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