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Demyelinating encephalopathy in Lyme disease

Departments of Neurolopy (Dr. Reik) and Psychiatry (Drs. Smith, Khan, and Nelson). University of Connecticut Health Center, Farmington, and the Neurology (Dr. Reik) and Psychiatry Services (Drs. Smith, Khan, and Nelson), VA Medical Center, Newington. CT.

A 38-year-old man from southeastern Connecticut developed a diffuse encephalopathy with partial complex seizures, followed weeks later by arthritis, cryoglobulinemia, and increased serum IgM. CT showed confluent low-density lesions in the deep cerebral white matter consistent with demyelination. Neither the encephalopathy nor the CT abnormalities improved. Lyme disease was diagnosed serologically 4 years later.

Address correspondence and reprint requests to Dr. Reik, Department of Neurology, University of Connecticut Health Center, 263 Farmington Avenue. Farmington, CT 06032.

Accepted for publication May 21, 1984.

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