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Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, and Department of Neurology, University of Minnesota Medical School, Minneapolis (Dr. Mortimer); Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis (Drs. French and Schuman): and Department of Medical and Surgical Neurology, School of Medicine, Texas Tech University, Lubbock, TX (Dr. Hutton).
A case-control study was performed in which the frequency of prior head injury was assessed in 78 patients with dementia of the Alzheimer type (DAT) and 124 control subjects matched for age, sex, and race. A history of head injury with loss of consciousness was reported in 25.6% of patients and 5.3% and 14.6% of hospital and neighborhood controls, respectively. Matched-pair analysis of patients and hospital controls yielded an odds ratio of 4.50, which was significant (p < 0.01). The ranges of times of occurrence of head injuries were similar in patients and controls, spanning several decades. The findings suggest a possible etiologic role for head injury in DAT.
Address correspondence and reprint requests to Dr. Mortimer, GRECC (11G). VA Medical Center, Minneapolis, MN 55417.
Supported by a grant from the National Institute of Aging, No. RO1-AG01529.
Presented in part at the thirty-fifth annual meeting of the American Academy of Neurology, San Diego, CA, April 1983.
Accepted for publication June 6, 1984
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