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HLA-DR antigens in multiple sclerosis

Two-dimensional gel electrophoresis

Departments of Neurology (Dr. Sriram), and Pathology, (Drs. Grumet and Engleman). Stanford University Medical Center, Stanford, CA, and Immunology Unit, Department of Medicine (Drs. Stewart and Bubler), Westmead Centre, Sydney, Australia.

Fifty to eighty percent of white patients with clinically definite MS express the DR2 antigen. In patients and normal controls who possess the DR2 antigens, analysis of the polymorphic light chain by two-dimensional polyacrylamide gel electrophoresis revealed no structural differences.

Address correspondence and reprint requests to Dr. Sriram, Room C-450, Given Bldg., Dept. of Neurology, University of Vermont Medical Center, Burlington, VT 05405.

Accepted for publication June 13, 1984

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