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L-dopa-induced respiratory disturbance in Parkinson's disease suppressed by tiapride

Departments of Neurology (Dr. De Keyser) and Internal Medicine (Dr. Vincken), Akademisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium.

L-dopa treatment provoked an irregular breathing pattern and dyspnea in a patient with Parkinson's disease. This side effect strongly limited adequate antiparkinsonian treatment with L-dopa. Simultaneous administration of L-dopa and tiapride resulted in improvement of parkinsonian symptoms and suppressed the respiratory side effect completely.

Address correspondence and reprint requests to Dr. De Keyser, Department of Neurology, Akademisch Ziekenhuis V. U. B., Laarbeeklaan 101, B-1090 Brussels, Belgium.

Accepted for publication May 4, 1984.

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