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Attempts to implicate viruses in myasthenia gravis

Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, and the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.

We investigated the hypothesis that a persistent viral infection of the thymus gland might trigger the autoimmune disease myasthenia gravis (MG). Thymus glands of nine patients with recent onset of MG were studied by a variety of techniques to detect the presence of occult viruses. No evidence of viral infection was found.

Address correspondence and reprint requests to Dr. Drachman, Johns Hopkins School of Medicine, Department of Neurology/Neuromuscular Unit, 600 North Wolfe Street, 5–119 Meyer Building, Baltimore, MD 21205.

Tomonobu Aoki was a Visiting Fellow from the Department of Microbiology, School of Medicine, Kyushu University, Fukuoka, Japan.

Accepted for publication May 29, 1984.

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