Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ohi, T.
Right arrow Articles by Dyck, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ohi, T.
Right arrow Articles by Dyck, P. J.
NEUROLOGY 1985;35:1790
© 1985 American Academy of Neurology

Increased endoneurial albumin in diabetic polyneuropathy

Takekazu Ohi, Joseph F. Poduslo and Peter J. Dyck

From the Membrane Biochemistry Laboratory, Peripheral Nerve Center, Neurology and Biochemistry, Mayo Clinic and Mayo Foundation, Rochester, MN.

Albumin was measured in the endoneurium of fascicular biopsies of sural nerves and in plasma from diabetic patients with polyneuropathy by solid phase radioimmunoassay, and normalized to total endoneurial and plasma protein, respectively, to obtain an index of the blood-nerve barrier (BNB-Index). Fifteen diabetic patients with polyneuropathy had a mean BNB-Index of 29.7 ± 12.6% SD, 3.8 times higherthan control values (7.8 ± 2.0% SD, n = 4).These data suggest that the blood-nerve barrier of endoneurial capillaries is impaired in patients with diabetic polyneuropathy.

Address correspondence and reprint requests to Dr. Poduslo, Membrane Biochemistry Laboratory, Neurology and Biochemistry, Mayo Clinic and Mayo Foundation, Rochester, MN 55905.

Supported in part by a Peripheral Neuropathy Clinical Center Grant from NINCDS (NS14304) and the Borchard Fund.

Accepted for publication April 10, 1985




This article has been cited by other articles:


Home page
 JAMAHome page
R. H. Griffey, R. P. Eaton, R. R. Sibbitt, W. L. Sibbitt Jr, and J. M. Bicknell
Diabetic Neuropathy: Structural Analysis of Nerve Hydration by Magnetic Resonance Spectroscopy
JAMA, November 18, 1988; 260(19): 2872 - 2878.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by AAN Enterprises, Inc.