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Isoniazid for tremor in multiple sclerosis

A controlled trial

From the Multiple Sclerosis Clinic, Notre-Dame Hospital (Dr. Duquette and Ms. Pleines), and the Department of Pharmacology. University of Montreal (Dr. du Souich), Montreal, Quebec, Canada.

We evaluated the effects of isoniazid on tremor in 13 patients with MS. Patients were evaluated before treatment, after 1 month of therapy (1,000 mg daily), and 1 month after the 1ast dose. Ten patients improved on at least one of three methods of evaluation. Transient side effects were common, possibly because there was a high percentage of "slow acetylators"; dosage was reduced by one-half in five patients. Improvement was mild and did not result in significant functional improvement.

Address correspondence and reprint requests to Dr. Duquette, Hôpital Nutre-Dame, Case Postale 1560, Station C, Montréal, Québec, Canada H2L 4K8.

This work was made possihle, in part, by grants from the Canadian MS Society and from La Fondation Notre-Dame. Huffmann-La Roche supplied part of the drug used in this trial.

Accepted for puhlication March 14, 1985.