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Incidence of seizures with phenytoin toxicity

From the Department of Neurology, Yale University School of Medicine, New Haven, CT; and the Veterans Administration Medical Center, West Haven, CT.

We reviewed ambulatory cassette EEG (A/EEG) records of 500 patients. Epileptiform abnormalities, seizures, or both were detected in 87 patients (17.4%), including 22 who were not taking anticonvulsant drugs. Epileptiform abnormalities were found in 1.5% of patients with syncope and in none without a clear history of episodic complaints. Abnormalities were found in 5.1% of patients referred by nonneurologic physicians. Some clinical seizures were not accompanied by A/EEG change and some episodes were not seizures, despite detection of epileptiform abnormalities.

Address Correspondence and reprint requests to Dr. Bridgers, Neurology Service (127), VA Medical Center, West Spring Street, West Haven, CT 06516.

Supported in part by the Epilepsy Foundation of America.

Presented at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX, May 1985.

Accepted for publication March 27, 1985

This article has been cited by other articles:

				S. L. Bridgers, P. B. Wade, and J. S. Ebersole Estimating the Importance of Epileptiform Abnormalities Discovered on Cassette Electroencephalographic Monitoring Arch Neurol, October 1, 1989; 46(10): 1077 - 1079. [Abstract] [PDF]

				S. L. Bridgers Ambulatory Cassette Electroencephalography of Psychiatric Patients Arch Neurol, January 1, 1988; 45(1): 71 - 74. [Abstract] [PDF]