Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thal, L. J.
Right arrow Articles by Waltz, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thal, L. J.
Right arrow Articles by Waltz, J. M.
NEUROLOGY 1985;35:1742
© 1985 American Academy of Neurology

Ventricular fluid somatostatin concentration decreases in childhood-onset dystonia

Leon J. Thal, MD, Nansie S. Sharpless, PhD, Daniel Rosenbaum, MD, Peter Davies, PhD, Ismail M. Amin, MD and Joseph M. Waltz, MD

From the Departments of Neurology (Drs. Thal, Sharpless, and Rosenbaum), Psychiatry (Dr. Sharpless), and Pathology (Dr. Davies), Albert Einstein College of Medicine, Bronx, NY; the Center for Physiological Neurosurgery at Westchester County Medical Center (Dr. Amin), Valhalla, NY; and the Department of Neurological Surgery (Dr. Waltz), St. Barnabas Hospital, Bronx, NY.

Somatostatin was measured in CSF from individuals with a variety of neurologic diseases. In ventricular CSF, somatostatin concentration was significantly lower in individuals with childhood-onset dystonia than in individuals with other forms of dystonia or with other disorders. Severity of childhood dystonia correlated with somatostatin concentration, suggesting a progressive dysfunction of somatostatin-containing neurons with increasing disease severity. There were no significant differences in somatostatin concentration in lumbar CSF. Multiple forms of immunoreactive somatostatin were found in a pool of lumbar CSF from normal individuals. Labeled somatostatin administered intra-arterially to rats failed to cross the blood-brain barrier.

Address correspondence and reprint requests to Dr. Thal, Chief of Neurology (127), San Diego VA Medical Center, 3350 La Jolla Village Drive, La Jolla, CA 92161.

Supported by a grant from the Dystonia Medical Research Foundation and by NIH grants NS09649 and AG02478.

Accepted for publication April 3, 1985






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by AAN Enterprises, Inc.