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A reliable method for localizing deep intracranial sources of the EEG

From the Department of Neurology (Dr. Smith), VA Medical Center, and Eastern Virginia Medical School, Hampton, VA; the Department of Mathematics and Statistics (Dr. Sidman), University of Southwestern Louisiana, Lafayette, LA; the Department of Surgery (Neurosurgery) (Dr. Flanigin), Medical College of Georgia, the VA Medical Center (Mr. Henke), and the Medical College of Georgia (Dr. Labiner), Augusta, GA.

We have demonstrated the reliability of a noninvasive method for successfully localizing the intracranial origin of the EEG. The dipole localization method (DLM) is a computer-assisted, mathematical method based on electrical field theory and is similar to localization methods currently used by electrocardiologists. In 12 patients with intractable epilepsy who were being evaluated for surgery, a known current source was introduced between two adjacent depth electrodes. Using scalprecorded EEG only, DLM accurately and reliably localized the source to within 2 cm of the known origin in all instances where a discrete source was present. We conclude that DLM is a valid and reliable noninvasive method for localizing the intracranial source of some scalp-recorded EEG potentials, and that in some patients, use of this method may obviate the need for depth electrode implantation.

Address correspondence and reprint requests to Dr. Smith, VA Medical Center, Hampton, VA 23667.

Supported in part by the Veterans Administration and by NIH Grant #AG-02030-2

Accepted for publication March 13, 1985.

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