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NEUROLOGY 1985;35:1695
© 1985 American Academy of Neurology

Comparison of glucose metabolism, x-ray CT, and postmortem data in a patient with multiple cerebral infarcts

E. Jeffrey Metter, MD, John C. Mazziotta, MD, PhD, Hideo H. Itabashi, MD, Nicholas J. Mankovich, PhD, Michael E. Phelps, PhD and David E. Kuhl, MD

From the Veterans Administration Medical Center (Dr. Metter), Sepulveda, CA; and Los Angeles County, Harbor-UCLA Medical Center (Dr. Itabashi), Departments of Neurology (Drs. Metter, Mazziotta, and Itabashi), Pathology (Dr. Itabashi), and Radiology (Dr. Mankovich), Division of Nuclear Medicine and Biophysics (Drs. Mazziotta, Kuhl, and Phelps), and Laboratory of Nuclear Medicine (Drs. Metter, Mazziotta, Phelps. and Kuhl), the School of Medicine, University of California, Los Angeles, CA.

We studied a 69-year-old man with multiple brain infarcts who died 8 days after being studied with positron emission tomography and (F-18)-fluorodeoxyglucose. Metabolic abnormalities were greater than structural changes in size and extent. They were found in areas with no gross pathologic abnormalities. Remote metabolic effects were attributed both to degeneration of fiber tracts with disconnection of remote structures, as demonstrated by hypometabolism in the left frontal cortex associated with an infarct in the genu of the left internal capsule, and to microscopic infarcts not apparent on gross examination but manifested as hypometabolic regions.

Address correspondence and reprint requests to Dr. Metter, Department of Neurology, Veterans Administration Medical Center, 16111 Plummer Street, Sepulveda, CA 91343.

This study was funded in part by Department of Energy Contract #DE-AM03-76-SS00012, and US Public Health Service Research Grants RO1-GM-24839 and PO1-NS-15654.

Dr. Mazziotta is the recipient of Teacher Investigator award 1K07-NS-0058804 from NINCDS.

Presented in part at the thirty-fifth annual meeting of the American Academy of Neurology, San Diego, CA, April 1983.

Accepted for publication March 25, 1985.




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