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Cerebral metabolism in hyper- and hypocarbia

³¹P and ¹H nuclear magnetic resonance studies

From the Department of Neurology (Drs. Petroff and Prichard) and the Department of Molecular Biophysics and Biochemistry (Drs. Behar, Rothman, Alger, and Shulman), Yale University, New Haven, CT.

Paralyzed rabbits ventilated with an oxygen, nitrous oxide, and carbon dioxide mixture were subjected to hyper- and hypocarbic stress. An Oxford Instrument TMR 32–200 spectrometer was used to record phosphorus-31 and nonwater proton nuclear magnetic resonance spectra of the in vivo brain. These spectra provide measurements of cerebral pHi, phosphocreatine, orthophosphate, ATP, and lactate. The brain exhibited twice as much acute pH-regulating ability as the arterial blood. During hypercarbia, orthophosphate rose while phosphocreatine declined in a reciprocal manner, and ATP remained constant. During hypocarbia, lactate rose gradually over a period of 1 hour, while orthophosphate, phosphocreatine, and ATP remained constant and calculated values of adenosine mono- and diphosphate rose.

Address correspondence and reprint requests to Dr. Prichard, Department of Neurology, Yale University, 333 Cedar Street, New Haven, CT 06510.

Supported by grant GM 30267 from the US Public Health Service and a grant from the Esther A. and Joseph Klingenstein Foundation.

Accepted for publication March 28, 1985.

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