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Disseminated abnormalities of cardiovascular autonomic functions in multiple sclerosis

From the Departments of Neurology (Drs. Sterman, Coyle, and Mr. Panasci) and Community and Preventive Medicine (Dr. Grimson), School of Medicine, SUNY at Stony Brook, Stony Brook, NY, and VA Medical Center, Northport, NY.

To determine whether patients with MS had abnormalities of autonomic cardiovascular functions, we evaluated 22 MS patients and 20 control subjects with a battery of six standardized tests. The two groups differed on three tests: heart rate and blood pressure responses to standing, and the cold-face test. One-half of the MS patients had abnormalities on two or more tests, but individual patients showed diverse abnormality patterns. Abnormalities of neural cardiovascular regulation are frequent in MS patients and show a heterogeneous pattern, consistent with scattered plaques.

Address correspondence and reprint requests to Dr. Sterman, Department of Neurology, School of Medicine, SUNY at Stony Brook, Stony Brook, NY 11794.

Supported in part by New Investigator Research Award ES-02650 and grant ES-03511 (AB Sterman) and Teacher Investigator Award NS-00790 (PK Coyle) from the NIH and by the Veterans Administration.

Presented in part at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX, April 1985.

Accepted for publication February 12, 1985.

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