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Autoradiographic localization of thyrotropin-releasing hormone receptors in amyotrophic lateral sclerosis spinal cord

From the Departments of Biology (Dr. Manaker), Pharmacology (Drs. Shulman, Winokur, and Rainbow), and Psychiatry (Dr. Winokur), University of Pennsylvania, Philadelphia, PA.

We used quantitative autoradiography to determine the density of thyrotropin-releasing hormone (TRH) receptors in discrete regions of spinal cord from four Datients with amvotrophic lateral sclerosis (ALS). The density and distribution of [³H]-3-methyl-histidine¹-TRH binding to TRH receptors differed from reported values in normal individuals, with fewer TRH receptors in lamina II and lamina IX. The diminished concentration of TRH receptors in lamina IX may reflect the loss of motor neurons in ALS.

Address correspondence and reprint requests to Dr. Manaker, Department of Pharmacology/G3, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.

Portions of this work were completed by the first author in partial fulfillment of the PhD degree from the University of Pennsylvania. This work has been supported by Medical Scientist Training Program NIH 5-T32-GM07170 to S.M.; NIH-STER 5-T32-HD-07217-03 to L.H.S.; NIMH Research Scientist Development Award MH00044 and NIH NS 18332 to A.W.; and NS 19597, NS 20006, and fellowships from the Alfred P. Sloan Foundation and the Esther A. and Joseph Klingenstein Fund to T.C.R.

Accepted for publication March 7, 1985.

This article has been cited by other articles:

				S. C. Miller and J. E. Warnick Protirelin (Thyrotropin-Releasing Hormone) in Amyotrophic Lateral Sclerosis: The Role of Androgens Arch Neurol, March 1, 1989; 46(3): 330 - 335. [Abstract] [PDF]