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NEUROLOGY 1985;35:1642
© 1985 American Academy of Neurology

Antigen-specific proliferation of CSF lymphocytes in Lyme disease

A. R. Pachner, A. C. Steere, L. H. Sigal and C. J. Johnson

From the Departments of Neurology (Dr. Pachner) and Internal Medicine (Drs. Steere, Sigal, and Johnson), Yale University School of Medicine, New Haven, CT.

The neurologic manifestations of Lyme disease include meningitis, radiculoneuritis, and cranial neuritis. In two patients, we investigated the proliferative response of CSF and peripheral blood lymphocytes to protein antigens derived from the Lyme disease spirochete. The response of CSF lymphocytes was 5 to 10 times greater than that of peripheral blood lymphocytes. In contrast, in the one patient studied, lectin-induced proliferation was less in CSF than in peripheral blood. These findings show that the CSF of patients with Lyme meningitis is an enriched source of antigen-specific proliferative lymphocytes.

Address correspondence and reprint requests to Dr. Pachner, Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510.

Supported by grants AM-20358, AM-07107, A1-07174, RR-00125, and RR-0543 from the National Institutes of Health and by the Arthritis Foundation and its Connecticut Chapter.

Accepted for publication February 14, 1985.




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