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Senile dementia of Alzheimer's type (SDAT)

Reduced T8+-cell-mediated suppressor activity

From the Departments of Neurology (Drs. Skias, Bania, Reder, and Antel) and Psychiatry (Dr. Luchins) and the Brain Research Institute, The University of Chicago, Chicago, IL.

We compared patients with senile dementia of the Alzheimer's type (SDAT) and age-matched controls with respect to T8^– -cell-mediated suppressor function using a pokeweed mitogen (pwm)-induced IgG secretion assay. The responding B cells were allogeneic to the T-regulator cells. T8-cell-mediated suppression was lower in SDAT patients than the controls when we used either 2 x 10⁴ or 5 x 10⁴ T8 cells. Suppressor function was lower in both SDAT and elderly controls than in young adults. SDAT patients and controls did not differ with regard to T4⁺ -cell-mediated helper activity. In SDAT patients, there seems to be an exaggeration of the age-related decline in suppressor-cell function. Whether such changes reflect accelerated changes of intrinsic lymphocyte properties or aberrant neural influences on lymphocytes remains to be resolved.

Address correspondence and reprint requests to Dr. Antel, Department of Neurology University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637.

Supported by grants from the Alzheimer Foundation and NIH AG01798.

Accepted for publication February 15, 1985.

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