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NEUROLOGY 1985;35:1576
© 1985 American Academy of Neurology

Nervous system brucellosis

Diagnosis and treatment

Rifaat Bashir, MD, FAAN, M. Zuheir Al-Kawi, MD, FAAN, Edward J. Harder, MD, FRCP(C) and John Jinkins, MD

From the Departments of Medicine (Drs. Bashir, Al-Kawi, and Harder) and Radiology (Dr. Jinkins), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

We treated six patients with nervous system brucellosis causing polyradiculitis (2 patients), myelopathy (2), encephalitis (1), or meningitis (1). Diagnosis was based on Brucella species cultured from one patient, and a twofold or greater rise in antibody titer after therapy was started in the others. Treatment with trimethoprim-sulfamethoxazole with rifampin (5 patients) or tetracycline (1 patient) produced excellent clinical and laboratory response.

Address correspondence and reprint requests to Dr Bashir, Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.

Accepted for publication March 7, 1985




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